[1] To determine my biological age, we have completed hundreds of biological age measurements on dozens of organs to date (see monthly notes for details). When we complete the remaining measurements, covering my 70 organs (ETA Q3 2022), we will use all measurements in a single biological age formula, with weightings for each organ based on their clinical relevance.  Until then, we are relying on 6 epigenetic clocks* to calculate whole body biological age.

*PCHorvath 1, PCHorvath 2, PCHannum, PC Phenoage, Age Horvath IEAA, Age Hannum IEAA

[2] As chlorella powder, yielding 13.5mg spermidine

[3]  Highest Quality Extra-Virgin Olive Oil
  • >400 HPLC (USA) measured total polyphenols or > 600 NMR measured (Europe)
  • >67% oleic 
  • < peroxide under 9 meq/kg 
  • < 0.3% free fatty acids (FFA)
  • >90% diacylglycerols 

[4] An older free testosterone index (FTI) is indicative of caloric restriction optimal nutrition (CRON) being deployed effectively; in the context of CRON the FTI is not representative of a high accuracy biological age marker of the testes, but rather to validate that CRON is being induced but not to such an extent that FTI is going too low and too old equivalent; typically a FTI of 40 - 60 represents this. FTI or total T below the normal range is likely unhealthy, and given CRON’s mechanism of action may partially act via lowering total T and FTI, it can be thought that T above the normal range for young men (or even upper quin/quartiles) could be suboptimal for longevity. Note that NIA mouse lifespan studies have shown male mice given oestrogen show reliable mean and maximum healthspan and lifespan extension and that the human male to female centenarian ratio can be as low as 1 to 10, theoretically partially mediated by the accelerated aging effect of higher testosterone to estrogen ratios, and higher absolute T and FTI.

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Medical disclaimer
This website, including any experimental results presented, is for informational purposes only and does not constitute medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease. Individuals seeking medical advice should consult with a licensed physician.

Biological age measurements and claims
Any claims regarding the measurement or reversal of biological age are preliminary and can be influenced by various biostatistical errors, including statistical variation, reference range relevancy, and clinical outcome significance. Ongoing, formal peer-reviewed studies are essential for validating these biological age tests for FDA approval (or its international equivalent) and confirming any clinically relevant changes in biological age. The data presented reflect our team's rigorous efforts to adhere to current scientific and biostatistical standards, while formal peer-reviewed validation studies are underway. Please note: These tests are experimental and intended solely for research purposes. They should not replace or supplement any clinical tests recommended by licensed medical professionals."

The protocol presented on this website is based on scientific research, ranging from mouse studies to meta-analyses of randomized controlled trials and international clinical practice guidelines. These have been carefully reviewed for their unique relevance to my personal situation. The protocol encompasses a mix of on-label, off-label, and unlicensed therapies, as well as research-use-only tests. Some of these tests and therapies are still under scientific investigation and have not yet received on-label licensing for specific health conditions. All tests and therapies, regardless of their licensing status, carry risks. These risks have been assessed for my personal use by a specialized team of clinicians and scientists. This protocol represents an experimental clinical research project. Results will be periodically published in peer-reviewed journals, adhering to international quality standards relevant to various types of clinical studies, including case reports, randomised controlled trials, and systematic reviews. Case reports, case series, and systematic reviews are important components of evidence-based medicine, helping inform the design of gold-standard randomised controlled trials and guiding clinical practice.

The use of Prescription only Medicines (PoMs) such as HGH, acarbose, rapamycin, metformin, thyroxine, testosterone, statins, phenylbutyric acid, tadalafil and others discussed in this protocol should not be considered an endorsement or promotion of these products. PoMs should only be prescribed by a licensed doctor who has assessed that the benefits and risks are acceptable for the individual and acquired through licensed pharmacies in a jurisdictionally legal manner. The prescribing doctor should be made aware of all other PoMs being taken and other relevant interventions such as foods, supplements and medical history to enable accurate assessment for safe prescribing and monitoring of combination interventions.

This web site is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.